Elderly inhabitants is rising rapidly: 35 % of the French population can be more than 60 years old in 2050, and within the inhabitants aged 65 or more, about 6 % of people suffer from Advert, while 17 % would suffer of "mild cognitive deficits". Occurrence of memory disorders is subsequently growing, and promoting healthy "memory" and treating memory diseases are of increasing priority. Memory degradation in aging and early phases of Alzheimer’s illness issues both brief-term and lengthy-time period memory elements. Regarding lengthy-time period memory, the 2 main varieties declining in aging are declarative and spatial memory, each of that are characterized by versatile expression. On this context, we propose rodent fashions that enable evaluating the totally different memory components degrading in aging, i.e. short-term memory maintenance focus and concentration booster updating, as well as long-term memory flexibility, and testing the unfavourable and positive results of recent psychoactive compounds on these features. These checks are performed using Morris water-maze process in rats. SAFMEM2B : Evaluation of the deleterious effects of latest compounds on long term working spatial memory in rodents.
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THERAPMEM 2 : Analysis of the pro-memory effect of latest compounds on long run working spatial memory in rodents. For working memory deficits: improvement of "The Village": A brand new automated apparatus for coupling with pharmacology research both cellular imaging of neuronal and vascular networks or optogenetics approaches. In "The Village", mice are reared socially in a posh surroundings that comprises desirable reward objects in numerous places. Automation of "The Village" permits increased throughput testing and improved reliability of knowledge recordings while minimizing interference with the experimenter. The automated version of the village can obtain a extremely progressive commutator for coupling, in freely transferring animals, fibred confocal microscopy (Cellvizio®) and pharmacology or optogenetics approaches and pharmacology. For spatial memory deficits: development of a water maze for coupling with optogenetics. This equipment combines a model of spatial memory (water-maze) to optogenetic instruments to ultimately perceive the neurobiological foundation of spatial memory disorders.

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